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Epidemiology and Risk Factors for Exocrine Pancreatic Cancer in a Northern African Population

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Abstract

Background

The etiology of pancreatic cancer remains largely unknown. Although epidemiological studies have reported that many environmental factors may contribute to the development of pancreatic cancer, only age and cigarette smoking have been established as consistent risk factors for the disease.

Objective

Studying the biological clinical and histological features of patients with pancreatic cancer in order to assess the possible risk factors for pancreatic cancer in a North African population.

Methods

An epidemiological retrospective descriptive study has been performed at the level of surgery department of the university hospital of Sidi bel Abbes region, western Algeria, from 2007 to 2013.

Results

A total of 87 patients were diagnosed with cancer of the pancreas (55 males and 32 females) with a mean age of 63.1 years, ranging from 16 to 96 years old, and a sex ratio of 1.71. In 92 % of cases, pancreatic tumors were located at the head of the pancreas; the most predominant histological type was the adenocarcinoma; cigarette smokers represented the rate of 24.3 % and alcoholics 13.5 %. The most recorded disease among patients medical history was diabetes mellitus (25.28 %). About 35.63 % was the prominent rate of patients who underwent cholecystectomy and was diagnosed with pancreatic cancer after an average duration of 5.23 years. Our patients were mostly diagnosed with cancer at M1 and T3 stages.

Conclusion

According to our results, cholecystectomy could possibly be a risk factor for pancreatic cancer in Algerian population

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References

  1. Jemal A, Siegel R, Ward E, Hao YP, Xu JQ, Murray T, et al. Cancer statistics. Ca: Cancer J Clin. 2008;58:71–96.

    Google Scholar 

  2. American Cancer Society. Cancer Facts & Figures 2014. Atlanta: American Cancer Society; 2014.

    Google Scholar 

  3. Michaud DS. Epidemiology of pancreatic cancer. Minerva Chir. 2004;59:99–111.

    CAS  PubMed  Google Scholar 

  4. Haddock G, Carter DC. Aetiology of pancreatic cancer. Br J Surg. 1990;77:1159–66.

    Article  CAS  PubMed  Google Scholar 

  5. Rivard N, Guan D, Maouyo D, Grondin G, Berube FL, Morisset J. Endogenous cholecystokinin release responsible for pancreatic growth observed following pancreatic juice diversion. Endocrinology. 1991;129:2867–74.

    Article  CAS  PubMed  Google Scholar 

  6. Marx M, Gomez G, Lonovics J, Thompson JC. Cholecystokinin. In: Greeley Jr GH, Rayford PL, Townsend Jr CM, Thompson JC, editors. Gastrointestinal endocrinology. New York: McGraw-Hilln; 1987. p. 213–22.

    Google Scholar 

  7. Hyvarinen H, Partanen S. Association of cholecystectomy with abdominal cancers. Hepatogastroenterology. 1987;34:280–4.

    CAS  PubMed  Google Scholar 

  8. Smith JP, Salomon TE, Bagheri S, Kramer S. Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990. Dig Dis Sci. 1990;35:1377–84.

    Article  CAS  PubMed  Google Scholar 

  9. Schiffman SC, Chu KC, Park J, et al. Is prior cholecystectomy associated with decreased survival in patients with resectable pancreatic adenocarcinoma following pancreaticoduodenectomy. Am J Surg. 2011;201:519–24.

    Article  PubMed  Google Scholar 

  10. Shibata A, Mack TM, Paganini-Hill A, Ross RK, Henderson BE. A prospective study of pancreatic cancer in the elderly. Int J Cancer. 1994;58:46–9. doi:10.1002/ijc.2910580109.

    Article  CAS  PubMed  Google Scholar 

  11. Lau MK, Davila JA, Shaib YH. Incidence and survival of pancreatic head and body and tail cancers: a population-based study in the United States. Pancreas. 2010;39:458–62. doi:10.1097/mpa.0b013e3181bd6489.

    Article  PubMed  Google Scholar 

  12. Ghadimi BM, Horstmann O, Jacobsen K, et al. Delay of diagnosis in pancreatic cancer due to suspected symptomatic cholelithiasis. Scand J Gastroenterol. 2002;37:1437–9.

    Article  CAS  PubMed  Google Scholar 

  13. Gray SH, Hawn MT, Kilgore ML, Yun H, Christein JD. Does cholecystectomy prior to the diagnosis of pancreatic cancer affect outcome? Am Surg. 2008;74(7):602–6 (5).

    PubMed  Google Scholar 

  14. Manousos O, Papadimitriou C, Trichopoulos D. Polychronopoulou A, Koutselinis A, Zavitsanos X. Epidemiologic characteristics and trace elements in pancreatic cancer in Greece. Cancer Detect Prev. 1981;4:439–42.

    CAS  PubMed  Google Scholar 

  15. GuIIo L, Pezzilli R, Morselli-Labate AM. Risk of pancreatic cancer associated with cholelithiasis, cholecystectomy, or gastrectomy. Dig Dis Sci. 1996;41:1065–8.

    Article  Google Scholar 

  16. Kalapothaki V, Tzonou A, Hsieh C, Toupadaki N, Karakatsani A, Trichopoulos D. Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as a risk factors for pancreatic carcinoma. Cancer Causes Control. 1993;4:375–82.

    Article  CAS  PubMed  Google Scholar 

  17. Marieb EN. Human Anatomy and Physiology: 4th ed. Menlo Park; 1998.

  18. Peeters TL, Vantrappen G, Janssens J. Bile acid output and the interdigestive migrating motor complex in normals and in cholecystectomy patients. Gastroenterology. 1980;79(4):678–81.

    CAS  PubMed  Google Scholar 

  19. Wagner M, Redaelli C, Lietz M, et al. Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg. 2004;91:586–94.

    Article  CAS  PubMed  Google Scholar 

  20. Sohn TA, Yeo CJ, Cameron JL, et al. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000;4:567–79.

    Article  CAS  PubMed  Google Scholar 

  21. Ferrone CR, Brennan MF, Gonen M, et al. Pancreatic adenocarcinoma: the actual 5-year survivors. J Gastrointest Surg. 2008;12:701–6.

    Article  PubMed  Google Scholar 

  22. Luman W, Williams AJ, Pryde A, Smith GD, Nixon SJ, Heading RC, et al. Influence of cholecystectomy on sphincter of Oddi motility. Gut. 1997;41:371–4.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Baldwin GS, Shulkes A. CCK receptors and cancer. Curr Top Med Chem. 2007;7:1232–8.

    Article  CAS  PubMed  Google Scholar 

  24. Miller LJ, Holicky EL, Ulrich CD, Wieben ED. Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity. Gastroenterology. 1995;109:1375–80.

    Article  CAS  PubMed  Google Scholar 

  25. Ding X, Lu CY, Mei Y, Liu CA, Shi YJ. Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus. HepatobiliaryPancreat. Dis Int. 2005;4:295–8.

    CAS  Google Scholar 

  26. Weinberg DS, Ruggeri B, Barber IMT, Biswas S, Miknyocki IS, Scott A. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. Am Soc Clin Invest. 1997;100(3):597–603.

    Article  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank the members of surgery departments of Sidi bel Abbes hospital for their invaluable support, guidance, and educational insight.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Biology, Djillali Liabes University, Sidi bel Abbes, Algeria

    Feriel Sellam, Noria Harir, Méghit B. Khaled, Nesrine M. Mrabent, Rachida Salah & Mustapha Diaf

  2. Department Laboratory of molecular microbiology, Djillali Liabes University, Sidi bel Abbes, Algeria

    Noria Harir

Authors
  1. Feriel Sellam
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  2. Noria Harir
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  3. Méghit B. Khaled
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  4. Nesrine M. Mrabent
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  5. Rachida Salah
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  6. Mustapha Diaf
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Correspondence to Feriel Sellam.

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Sellam, F., Harir, N., Khaled, M.B. et al. Epidemiology and Risk Factors for Exocrine Pancreatic Cancer in a Northern African Population. J Gastrointest Canc 46, 126–130 (2015). https://doi.org/10.1007/s12029-015-9693-4

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  • DOI: https://doi.org/10.1007/s12029-015-9693-4

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